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We are a synthetic chemistry group developing new methodologies to access molecules that can address unmet medical needs.

A major focus of our research is on employing, as well as developing organic synthesis methodology to enable, laboratory automation and artificial intelligence approaches to accelerate the discovery of complex biologically active molecules.

• Klucznik, T.†; Syntrivanis, L.-D.†*; BaÅ›, S.; Mikulak-Klucznik, B., Moskal, M.; Szymkuć, S.; Mlynarski, J.; Gadina, L.; Beker W.†*; Burke, M. D.*; Tiefenbacher K.*; Grzybowski B. A.*, Computational prediction of complex cationic rearrangement outcomes. Nature 2024, 625, 508-515
• Cornu, I.†; Syntrivanis, L.-D.†; Tiefenbacher, K., Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst. Nat. Protoc. 2024, 19, 313-339
• Syntrivanis, L.-D.; Némethová, I.; Schmid, D.; Levi, S.; Prescimone, A.; Bissegger, F.; Major, D. T.; Tiefenbacher, K., Four-Step Access to the Sesquiterpene Natural Product Presilphiperfolan-1β-ol and Unnatural Derivatives via Supramolecular Catalysis. J. Am. Chem. Soc. 2020, 142 (12), 5894-5900

(† equal contribution; * corresponding author)